Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRKAG2
  • Mouse genes Prkag2
  • Rat genes Prkag2
  • Zfish genes prkag2a,prkag2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkag2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	PRKAG2	IDA		Human	PMID:15877279
Molecular Function	GO:0016208	AMP binding	Prkag2	IDA		Rat	PMID:16648175|RGD:1600447
Molecular Function	GO:0004679	AMP-activated protein kinase activity	Prkag2	IMP		Rat	PMID:10698692|RGD:1600480
Molecular Function	GO:0004679	AMP-activated protein kinase activity	Prkag2	IDA		Rat	PMID:16648175|RGD:1600447
Molecular Function	GO:0005524	ATP binding	PRKAG2	IDA		Human	PMID:15877279
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	PRKAG2	IDA		Human	PMID:17255938
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	PRKAG2	IMP		Human	PMID:15877279
Molecular Function	GO:0008607	phosphorylase kinase regulator activity	PRKAG2	IMP		Human	PMID:15877279
Molecular Function	GO:0005515	protein binding	PRKAG2	IPI	UniProtKB:I6L9F6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRKAG2	IPI	UniProtKB:Q13501	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRKAG2	IPI	UniProtKB:Q8NE08	Human	PMID:32814053
Molecular Function	GO:0030295	protein kinase activator activity	PRKAG2	IMP		Human	PMID:15877279
Molecular Function	GO:0019901	protein kinase binding	PRKAG2	IDA		Human	PMID:10698692
Molecular Function	GO:0019901	protein kinase binding	Prkag2	IPI	RGD:3387	Rat	PMID:16648175|RGD:1600447
Molecular Function	GO:0019901	protein kinase binding	Prkag2	IPI	RGD:620893	Rat	PMID:16648175|RGD:1600447
Cellular Component	GO:0005615	extracellular space	PRKAG2	HDA		Human	PMID:22664934
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	PRKAG2	IDA		Human	PMID:15877279
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	Prkag2	IDA		Rat	PMID:10698692|RGD:1600480
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	Prkag2	IDA		Rat	PMID:16648175|RGD:1600447
Biological Process	GO:0005977	glycogen metabolic process	PRKAG2	IMP		Human	PMID:11827995
Biological Process	GO:0005977	glycogen metabolic process	PRKAG2	IMP		Human	PMID:15877279
Biological Process	GO:0035556	intracellular signal transduction	PRKAG2	IMP		Human	PMID:15877279
Biological Process	GO:0006469	negative regulation of protein kinase activity	PRKAG2	IDA		Human	PMID:17255938
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	PRKAG2	IMP		Human	PMID:15877279
Biological Process	GO:0045860	positive regulation of protein kinase activity	PRKAG2	IMP		Human	PMID:15877279
Biological Process	GO:0050790	regulation of catalytic activity	Prkag2	IDA		Rat	PMID:16648175|RGD:1600447
Biological Process	GO:0019217	regulation of fatty acid metabolic process	PRKAG2	IMP		Human	PMID:15877279
Biological Process	GO:0006110	regulation of glycolytic process	PRKAG2	IMP		Human	PMID:15877279

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern