Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MYH11
  • Mouse genes Myh11
  • Rat genes Myh11
  • Zfish genes myh11a,myh11b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Myh11

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003774	cytoskeletal motor activity	Myh11	IMP	MGI:MGI:2656492	Mouse	PMID:10854329
Molecular Function	GO:0005515	protein binding	MYH11	IPI	UniProtKB:O14950	Human	PMID:19328794
Molecular Function	GO:0008307	structural constituent of muscle	MYH11	IMP		Human	PMID:16444274
Cellular Component	GO:0005903	brush border	Myh11	IDA		Mouse	MGI:MGI:5621262|PMID:22114352
Cellular Component	GO:0070062	extracellular exosome	MYH11	HDA		Human	PMID:23533145
Cellular Component	GO:0005859	muscle myosin complex	Myh11	IDA		Mouse	PMID:10854329
Cellular Component	GO:0005859	muscle myosin complex	Myh11	IDA		Mouse	PMID:11715025
Cellular Component	GO:0016459	myosin complex	Myh11	IDA		Mouse	PMID:8593698
Cellular Component	GO:0030485	smooth muscle contractile fiber	Myh11	IDA		Mouse	PMID:11715025
Cellular Component	GO:0001725	stress fiber	Myh11	IDA		Mouse	PMID:8593698
Biological Process	GO:0008015	blood circulation	myh11a	IMP	ZFIN:ZDB-GENO-160812-1	Zfish	PMID:26893369
Biological Process	GO:0008015	blood circulation	myh11a	IMP	ZFIN:ZDB-GENO-121022-1	Zfish	PMID:26893369
Biological Process	GO:0055013	cardiac muscle cell development	MYH11	IMP		Human	PMID:16444274
Biological Process	GO:0048565	digestive tract development	myh11a	IMP	ZFIN:ZDB-GENO-980202-444	Zfish	PMID:9007252
Biological Process	GO:0048546	digestive tract morphogenesis	myh11a	IMP	ZFIN:ZDB-GENO-121022-1	Zfish	PMID:22973180
Biological Process	GO:0048546	digestive tract morphogenesis	myh11a	IMP	ZFIN:ZDB-GENO-980202-444	Zfish	PMID:15866162
Biological Process	GO:0048251	elastic fiber assembly	MYH11	IMP		Human	PMID:16444274
Biological Process	GO:0060047	heart contraction	myh11a	IMP	ZFIN:ZDB-GENO-121022-1	Zfish	PMID:26893369
Biological Process	GO:0060047	heart contraction	myh11a	IMP	ZFIN:ZDB-GENO-160812-1	Zfish	PMID:26893369
Biological Process	GO:0072593	reactive oxygen species metabolic process	myh11a	IMP	ZFIN:ZDB-GENO-121022-1	Zfish	PMID:22973180
Biological Process	GO:0030860	regulation of polarized epithelial cell differentiation	myh11a	IMP	ZFIN:ZDB-GENO-980202-444	Zfish	PMID:15866162
Biological Process	GO:0006939	smooth muscle contraction	Myh11	IMP	MGI:MGI:3576856	Mouse	PMID:12562924
Biological Process	GO:0006939	smooth muscle contraction	Myh11	IDA		Mouse	PMID:11715025
Biological Process	GO:0006939	smooth muscle contraction	Myh11	IMP	MGI:MGI:2656492	Mouse	PMID:10854329

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern