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Myh11 Gene Detail
Summary
  • Symbol
    Myh11
  • Name
    myosin, heavy polypeptide 11, smooth muscle
  • Synonyms
    SM1, SM2, smMHC
  • Feature Type
    protein coding gene
  • IDs
    MGI:102643
    NCBI Gene: 17880
  • Gene Overview
    MyGene.info: MYH11
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:14194527-14291408 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      96882 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 9.71 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    MYH11, myosin heavy chain 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYH11, myosin heavy chain 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAT4, FAA4, SMHC, SMMHC
  • Links
    NCBI Gene ID: 4629
    neXtProt AC: NX_P35749
    UniProt: P35749

  • Chr Location
    16p13.11; chr16:15703135-15857032 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 128512
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYH11
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MYH11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 5 alleles in 4 genetic backgrounds
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have impaired smooth muscle contractility. They are incapable of urinating, exhibit dilative cardiomyopathy, are growth retarded, and die within 3 days of birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17880 NCBI Gene Model | MGI Sequence Detail 96882 C57BL/6J ±  kb
    transcript NM_013607 RefSeq | MGI Sequence Detail 6632 C57BL/6  
    polypeptide O08638 UniProt | EBI | MGI Sequence Detail 1972 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      595 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR000048 IQ motif, EF-hand binding site
      IPR036961 Kinesin motor domain superfamily
      IPR001609 Myosin head, motor domain
      IPR027401 Myosin IQ motif-containing domain superfamily
      IPR004009 Myosin, N-terminal, SH3-like
      IPR008989 Myosin S1 fragment, N-terminal
      IPR002928 Myosin tail
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 69
      Primer pair 6
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-19534, MGI:2139931
    References
    more
    • Summaries
      All 147
      Developmental Gene Expression 92
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:4725 Matsuoka R, et al., Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12. Am J Med Genet. 1993 Apr 1;46(1):61-7
    • Latest
      J:253459 Inoue SI, et al., Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice. Hum Mol Genet. 2017 Dec 1;26(23):4715-4727

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory