About   Help   FAQ
Myh11 Gene Detail
Summary
  • Symbol
    Myh11
  • Name
    myosin, heavy polypeptide 11, smooth muscle
  • Synonyms
    SM1, SM2, smMHC
  • Feature Type
    protein coding gene
  • IDs
    MGI:102643
    NCBI Gene: 17880
Location & Maps
more
  • Sequence Map
    Chr16:14194527-14291408 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      96882 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MYH11, myosin, heavy chain 11, smooth muscle
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYH11, myosin, heavy chain 11, smooth muscle
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AAT4, FAA4, SMHC, SMMHC
  • Links
    NCBI Gene ID: 4629
    neXtProt AC: NX_P35749

  • Chr Location
    16p13.11; chr16:15703135-15857033 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 128512
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MYH11
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MYH11 associations

Human Disease Mouse Models
       Aortic Aneurysm, Familial Thoracic 4; AAT4   OMIM: 132900
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 5 alleles in 4 genetic backgrounds
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice have impaired smooth muscle contractility. They are incapable of urinating, exhibit dilative cardiomyopathy, are growth retarded, and die within 3 days of birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17880 NCBI Gene Model | MGI Sequence Detail 96882 C57BL/6J ±  kb
transcript NM_013607 RefSeq | MGI Sequence Detail 6632 C57BL/6  
polypeptide O08638 UniProt | EBI | MGI Sequence Detail 1972 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    599 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 79
    cDNA 70
    Primer pair 6
    Other 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-19534, MGI:2139931
References
more
  • Summaries
    All 115
    Developmental Gene Expression 69
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:4725 Matsuoka R, et al., Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12. Am J Med Genet. 1993 Apr 1;46(1):61-7
  • Latest
    J:225747 Jayewickreme CD, et al., Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol. 2015 Sep 1;405(1):21-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory