Myh11
Gene Detail

Symbol Name ID

Myh11 myosin, heavy polypeptide 11, smooth muscle MGI:102643

Synonyms

SM1, SM2, smMHC

Feature Type

protein coding gene

Genetic Map

Chromosome 16

9.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr16:14194527-14291408 bp, - strand From NCBI annotation of GRCm38   96882 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128512  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Myh11

Human homologs

Human Homolog		MYH11, myosin, heavy chain 11, smooth muscle
NCBI Gene ID		4629
neXtProt AC		NX_P35749
Human Synonyms		AAT4, FAA4, SMHC, SMMHC
Human Chr (Location)		16p13.11; chr16:15796992-15950887 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MYH11

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mice have impaired smooth muscle contractility. They are incapable of urinating, exhibit dilative cardiomyopathy, are growth retarded, and die within 3 days of birth.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cardiac muscle fiber development, elastic fiber assembly, ...
Component	cytoplasm, muscle myosin complex, ...
Function	actin binding, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (50 records)
Data Summary: Results (239)    Tissues (153)    Images (51)
Theiler Stages: 13, 15, 19, 20, 21, 23, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	141
RT-PCR	84

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(14) Primer pair(5) Other(3)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000018830 (Evidence)
Entrez Gene	17880 (Evidence)
DFCI	TC1578231, TC1595368, TC1681786, TC1685513
DoTS	DT.534153, DT.101709503, DT.110728809, DT.60105066, DT.91341335, DT.97362284
NIA Mouse Gene Index	U036815
Consensus CDS Project	CCDS27972.1
International Mouse Knockout Project Status	Myh11

Sequences

Length	Strain/Species
genomic	17880	NCBI Gene Model | MGI Sequence Detail	96882	C57BL/6J
transcript	NM_013607	RefSeq | MGI Sequence Detail	6632	C57BL/6
polypeptide	O08638	UniProt | EBI | MGI Sequence Detail	1972	Not Applicable

All sequences(38) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(468 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR001609	Myosin head, motor domain
InterPro	IPR004009	Myosin, N-terminal, SH3-like
InterPro	IPR002928	Myosin tail
Protein Ontology	PR:000010822	myosin-11

Graphical View of Protein Domain Structure

References

(Earliest) J:4725 Matsuoka R, et al., Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12. Am J Med Genet. 1993 Apr 1;46(1):61-7
(Latest) J:193198 Wu B, et al., Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. Cell. 2012 Nov 21;151(5):1083-96
All references(96)

Other accession IDs

MGD-MRK-19534, MGI:2139931