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Myh11 Gene Detail
Summary
  • Symbol
    Myh11
  • Name
    myosin, heavy polypeptide 11, smooth muscle
  • Synonyms
    SM1, SM2, smMHC
  • Feature Type
    protein coding gene
  • IDs
    MGI:102643
    NCBI Gene: 17880
  • Gene Overview
    MyGene.info: MYH11
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:14194535-14291372 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 9.71 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    595 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102643
protein coding gene Chr16:14194527-14291408 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022543
protein coding gene Chr16:11242829-11343478 (-)
A/J MGP_AJ_G0022505
protein coding gene Chr16:10604147-10702296 (-)
AKR/J MGP_AKRJ_G0022481
protein coding gene Chr16:11074490-11171424 (-)
BALB/cJ MGP_BALBcJ_G0022509
protein coding gene Chr16:10780451-10878474 (-)
C3H/HeJ MGP_C3HHeJ_G0022276
protein coding gene Chr16:11172186-11274232 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022958
protein coding gene Chr16:11392836-11490775 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020478
protein coding gene Chr16:10696807-10795631 (-)
CAST/EiJ MGP_CASTEiJ_G0021803
protein coding gene Chr16:11192787-11301869 (-)
CBA/J MGP_CBAJ_G0022245
protein coding gene Chr16:11943450-12043022 (-)
DBA/2J MGP_DBA2J_G0022376
protein coding gene Chr16:10605633-10703048 (-)
FVB/NJ MGP_FVBNJ_G0022352
protein coding gene Chr16:10587871-10685112 (-)
LP/J MGP_LPJ_G0022444
protein coding gene Chr16:11125030-11230442 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022374
protein coding gene Chr16:11560747-11664259 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022971
protein coding gene Chr16:11048103-11148964 (-)
PWK/PhJ MGP_PWKPhJ_G0021545
protein coding gene Chr16:10860983-10960543 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021374
protein coding gene Chr16:11036069-11137794 (-)
WSB/EiJ MGP_WSBEiJ_G0021851
protein coding gene Chr16:11062159-11161278 (-)



Homology
more
  • Human Ortholog
    MYH11, myosin heavy chain 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYH11, myosin heavy chain 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAT4, FAA4, SMHC, SMMHC
  • Links
    NCBI Gene ID: 4629
    neXtProt AC: NX_P35749
    UniProt: P35749

  • Chr Location
    16p13.11; chr16:15703135-15857032 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 128512
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYH11
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MYH11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 5 alleles in 4 genetic backgrounds
    2 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have impaired smooth muscle contractility. They are incapable of urinating, exhibit dilative cardiomyopathy, are growth retarded, and die within 3 days of birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018830 Ensembl Gene Model | MGI Sequence Detail 96838 C57BL/6J ±  kb
    transcript ENSMUST00000231567 Ensembl | MGI Sequence Detail 6450 Not Applicable  
    polypeptide ENSMUSP00000156021 Ensembl | MGI Sequence Detail 1979 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR000048 IQ motif, EF-hand binding site
      IPR036961 Kinesin motor domain superfamily
      IPR001609 Myosin head, motor domain
      IPR027401 Myosin IQ motif-containing domain superfamily
      IPR004009 Myosin, N-terminal, SH3-like
      IPR008989 Myosin S1 fragment, N-terminal
      IPR002928 Myosin tail
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 70
      Primer pair 6
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-19534, MGI:2139931
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 95
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:4725 Matsuoka R, et al., Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12. Am J Med Genet. 1993 Apr 1;46(1):61-7
    • Latest
      J:263962 Wilczewski CM, et al., CHD4 and the NuRD complex directly control cardiac sarcomere formation. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6727-6732

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory