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Myh11
Gene Detail
Symbol

Name
ID
Myh11
myosin, heavy polypeptide 11, smooth muscle
MGI:102643
Synonyms
SM1, SM2, smMHC
Feature Type
protein coding gene
Genetic Map
Chromosome 16
9.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:14194527-14291408 bp, - strand
From NCBI annotation of GRCm38

  96882 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128512  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYH11
Gene Tree: Myh11

Human
homologs
MYH11, myosin, heavy chain 11, smooth muscle
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4629
neXtProt AC: NX_P35749

Human Synonyms: AAT4, FAA4, SMHC, SMMHC

Human Chr (Location): 16p13.11; chr16:15703135-15857033 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MYH11

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice have impaired smooth muscle contractility. They are incapable of urinating, exhibit dilative cardiomyopathy, are growth retarded, and die within 3 days of birth.
 
Phenotype Images(2)
Interactions
Myh11 interacts with 187 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process activation of mitophagy in response to mitochondrial depolarization, cardiac muscle fiber development, ...
Component brush border, cytoplasm, ...
Function actin binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (66 records)
Data Summary: Results (258)    Tissues (176)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 23
RNA in situ 147
RT-PCR 88
cDNA source data(70)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myh11 ; ZFIN myh11a    NEW 
Molecular
reagents
All nucleic(79) cDNA(70) Primer pair(6) Other(3)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000018830 (Evidence)
Entrez Gene 17880 (Evidence)
UniGene 250705
DFCI TC1681786, TC1595368, TC1578231, TC1685513
DoTS DT.534153, DT.110728809, DT.101709503, DT.91341335, DT.60105066, DT.97362284
NIA Mouse Gene Index U036815
Consensus CDS Project CCDS27972.1
International Mouse Phenotyping Consortium Status Myh11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17880 NCBI Gene Model | MGI Sequence Detail 96882 C57BL/6J ±  kb
transcript NM_013607 RefSeq | MGI Sequence Detail 6632 C57BL/6 
polypeptide O08638 UniProt | EBI | MGI Sequence Detail 1972 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(599 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010822 myosin-11
Graphical View of Protein Domain Structure
References
(Earliest) J:4725 Matsuoka R, et al., Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12. Am J Med Genet. 1993 Apr 1;46(1):61-7
(Latest) J:218158 Turner CJ, et al., alpha5 and alphav integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo. Development. 2015 Feb 15;142(4):797-808
All references(115)
Other
accession IDs
MGD-MRK-19534, MGI:2139931

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory