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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Aire

Graphs for Molecular Function, Cellular Component, Biological Process generated Mon Apr 26 17:39:58 2021.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aire
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003682chromatin bindingAIREIDAHumanPMID:18292755
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificAIREIMPHumanPMID:11274163
Molecular FunctionGO:0042393histone bindingAIREIDAHumanPMID:18292755
Molecular FunctionGO:0042393histone bindingAIREIDAHumanPMID:19446523
Molecular FunctionGO:0042802identical protein bindingAIREIPIUniProtKB:O43918HumanPMID:15712268
Molecular FunctionGO:0042802identical protein bindingAIREIPIUniProtKB:O43918HumanPMID:20185822
Molecular FunctionGO:0042802identical protein bindingAIREIPIUniProtKB:O43918HumanPMID:28540407
Molecular FunctionGO:0042802identical protein bindingAireIPIUniProtKB:Q9Z0E3MouseMGI:MGI:5294312|PMID:11533054
Molecular FunctionGO:0005515protein bindingAIREIPIUniProtKB:P16333HumanPMID:17474147
Molecular FunctionGO:0005515protein bindingAIREIPIUniProtKB:P68431HumanPMID:18292755
Molecular FunctionGO:0005515protein bindingAIREIPIUniProtKB:P78527HumanPMID:20085707
Molecular FunctionGO:0005515protein bindingAIREIPIUniProtKB:Q9UER7HumanPMID:20185822
Molecular FunctionGO:0000977RNA polymerase II transcription regulatory region sequence-specific DNA bindingAIREIDAHumanPMID:11533054
Molecular FunctionGO:0008270zinc ion bindingAIREIDAHumanPMID:19446523
Cellular ComponentGO:0005737cytoplasmAireIDAMouseMGI:MGI:1933721|PMID:11156688
Cellular ComponentGO:0005622intracellular anatomical structureAireIDAMouseMGI:MGI:3721213|PMID:17599412
Cellular ComponentGO:0016604nuclear bodyAireIDAMouseMGI:MGI:3818193|PMID:19015306
Cellular ComponentGO:0005634nucleusAireIDAMouseMGI:MGI:1933721|PMID:11156688
Cellular ComponentGO:0005634nucleusAireIDAMouseMGI:MGI:2182827|PMID:11854172
Biological ProcessGO:0002509central tolerance induction to self antigenAIREIMPHumanPMID:26084028
Biological ProcessGO:0032602chemokine productionAireIMPMouseMGI:MGI:4430981|PMID:19923453
Biological ProcessGO:0006959humoral immune responseAireIMPMGI:MGI:2182940MouseMGI:MGI:2182827|PMID:11854172
Biological ProcessGO:0045060negative thymic T cell selectionAireIGIMGI:MGI:1277186MouseMGI:MGI:5488556|PMID:23382543
Biological ProcessGO:0002458peripheral T cell tolerance inductionAireIDAMouseMGI:MGI:5562496|PMID:23993652
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIAIREIMPHumanPMID:11274163
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIAireIMPMGI:MGI:3722595MouseMGI:MGI:3721213|PMID:17599412
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIAireIDAMouseMGI:MGI:3721213|PMID:17599412
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedAIREIDAHumanPMID:18292755
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedAIREIMPHumanPMID:26084028
Biological ProcessGO:2000410regulation of thymocyte migrationAireIMPMouseMGI:MGI:4430981|PMID:19923453
Biological ProcessGO:0006355regulation of transcription, DNA-templatedAIREIDAHumanPMID:18292755
Biological ProcessGO:0097536thymus epithelium morphogenesisAireIMPMouseMGI:MGI:3818193|PMID:19015306

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory