Recombinase (cre) Activity
MGI collects and annotates expression and activity data for recombinase-containing transgenes and knock-in alleles.
Find recombinase-carrying alleles
Retrieve all alleles
Retrieve a list of all recombinase-containing transgenes and knock-in alleles.
Search for recombinase-containing transgene or knock-in alleles, or floxed or frt alleles using MGI's Allele Query Form
Search for endogenous gene expression using MGI's Gene Expression Data Query Form
How do I...
- find existing recombinase-expressing transgenes and knock-ins that have a given promoter (driver)? FAQ
- find the promoter (driver) that I'm looking for if it is not on the selection list? FAQ
- find a recombinase-containing transgene or knock-in that is expressed in a specific tissue? FAQ
- get a full list of all transgenes and knock-ins that express recombinase? FAQ
- order mice with a desired recombinase construct? FAQ
Cre Portal Tutorial
Recombinase Allele Data Include
|1000||Recombinase-containing knock-in alleles|
|2635||Total recombinase transgenes and alleles|
|678||Drivers in recombinase transgenes|
|652||Drivers in recombinase knock-in alleles|
|3590||Tissues in recombinase specificity assays|
Recombinase Project News
- Data about cre-containing transgenes and knock-ins and their tissue specific activity are being curated from the scientific literature and integrated from projects underway at collaborating organizations. (See the Collaborators tab, below).
- We are part of the CREATE (Coordination of resources for conditional expression of mutated mouse alleles) consortium.
- List of available strains expressing cre
|Cre is currently the most commonly used recombinase. It catalyzes site-specific recombination of DNA between loxP sites, thus making possible conditional mutagenesis, where specific genes can be knocked out in particular tissues and at particular developmental time points. Other non-cre recombinases (such as Flp, Dre, phiC31, etc.) and various inducible forms of recombinases have been and are being developed. We are curating data about all recombinase-containing transgenes and knock-ins developed in mice to provide a comprehensive resource delineating known activity patterns and allowing users to find relevant mouse resources for their studies.|
|Available data will continue to increase. To retrieve all recombinase-containing transgenes and knock-in alleles, use RETRIEVE ALL ALLELES, above.|
|The Recombinase Activity project is funded by NIH grants OD011190 and HD062499.|