Phenotypes for Aldh1a1 Aldh1a2 Plekha5 MGI:7327644 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1.1Mbp/Aldh1a2^tm1.2Mbp Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a1^tm1Gdu mutation (1 available); any Aldh1a1 mutation (39 available)
Aldh1a2^tm1.1Mbp mutation (0 available); any Aldh1a2 mutation (35 available)
Aldh1a2^tm1.2Mbp mutation (0 available); any Aldh1a2 mutation (35 available)
Plekha5^{Tg(AMH-cre)1Flor} mutation (1 available); any Plekha5 mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased Sertoli cell number ( J:324715 )

abnormal spermatogenesis ( J:324715 )

• block at the progression at the conversion of A spermatogonia to A1

• however, injection with retinoic acid restored spermatogenesis

azoospermia ( J:324715 )

male infertility ( J:324715 )

endocrine/exocrine glands

decreased Sertoli cell number ( J:324715 )

cellular

azoospermia ( J:324715 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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