Phenotypes for Gt(ROSA)26Sor Kras Tg(Pdx1-cre)6Tuv Trp53 MGI:6377671 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm1Brn/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (23 available); any Gt(ROSA)26Sor mutation (1098 available)
Kras^tm4Tyj mutation (12 available); any Kras mutation (88 available)
Tg(Pdx1-cre)6Tuv mutation (4 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:280854 )

• all mice die by 30 weeks of age

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:280854 )

• at 8 weeks

increased pancreatic intraepithelial neoplasia incidence ( J:280854 )

• at 8 weeks

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:280854 )

• at 8 weeks

increased pancreatic intraepithelial neoplasia incidence ( J:280854 )

• at 8 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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