Phenotypes for Cd9 Gt(ROSA)26Sor Kras Tg(Pdx1-cre)6Tuv Trp53 MGI:6377668 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd9^{tm1c(EUCOMM)Hmgu}/Cd9^{tm1c(EUCOMM)Hmgu} Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm1Brn/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd9^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Cd9 mutation (101 available)
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (24 available); any Gt(ROSA)26Sor mutation (1061 available)
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm1Brn mutation (20 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:280854 )

• as severe as in mice wild-type for Cd9

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:280854 )

• at 8 weeks, more severe than in mice heterozygous for the Cd9 conditional allele

endocrine/exocrine glands

increased pancreatic intraepithelial neoplasia incidence ( J:280854 )

• at 8 weeks, more severe than in mice heterozygous for the Cd9 conditional allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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