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Phenotypes Associated with This Genotype
Genotype
MGI:6256733
Allelic
Composition		 Albtm1(cre/ERT2)Mtz/Alb+
Krastm4Tyj/Kras+
Ptentm2Mak/Ptentm2Mak
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albtm1(cre/ERT2)Mtz mutation (2 available); any Alb mutation (92 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Ptentm2Mak mutation (4 available); any Pten mutation (86 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased cholangiocarcinoma incidence ( J:254370 )
• mice injected with tamoxifen at P10 develop liver tumors that are exclusively intrahepatic cholangiocarcinoma
increased hepatocellular carcinoma incidence ( J:254370 )
• mice injected with tamoxifen at 8 weeks after birth develop multiple liver tumors that are all hepatocellular carcinoma and hepatocellular dysplasia, but not intrahepatic cholangiocarcinoma

liver/biliary system
increased cholangiocarcinoma incidence ( J:254370 )
• mice injected with tamoxifen at P10 develop liver tumors that are exclusively intrahepatic cholangiocarcinoma
increased hepatocellular carcinoma incidence ( J:254370 )
• mice injected with tamoxifen at 8 weeks after birth develop multiple liver tumors that are all hepatocellular carcinoma and hepatocellular dysplasia, but not intrahepatic cholangiocarcinoma

endocrine/exocrine glands
increased cholangiocarcinoma incidence ( J:254370 )
• mice injected with tamoxifen at P10 develop liver tumors that are exclusively intrahepatic cholangiocarcinoma

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory