Phenotypes for Mdm4 Tg(Myh6-cre)2182Mds Trp53 MGI:5907135 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mdm4^tm2Glo/Mdm4^tm2.1Glo Tg(Myh6-cre)2182Mds/0 Trp53^tm1Tyj/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm2.1Glo mutation (0 available); any Mdm4 mutation (190 available)
Mdm4^tm2Glo mutation (1 available); any Mdm4 mutation (190 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
Trp53^tm1Brn mutation (20 available); any Trp53 mutation (237 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:137114 )

• mice die due to tumors not heart failure

extended life span ( J:137114 )

• mice show an extended mean survival of 403 days compared to compound heterozygous Mdm4^tm2Glo/Mdm4^tm2.1Glo conditional mutants

cardiovascular system

cardiovascular system phenotype ( J:137114 )

N	• mice do not exhibit signs of heart failure such as edema and poor breathing and exhibit rescue of the dilated cardiomyopathy

neoplasm

increased tumor incidence ( J:137114 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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