Phenotypes Associated with This Genotype

Genotype
MGI:5902077

• Allelic Composition: Rhox13^tm1.2Chge/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased male germ cell number ( J:237048 )

♂ • Background Sensitivity: some mice, presumably those with more 129 strain background, had extremely low cauda sperm counts

oligozoospermia ( J:237048 )

♂ • Background Sensitivity: some mice, presumably those with more 129 strain background, had extremely low cauda sperm counts

increased male germ cell apoptosis ( J:237048 )

♂ • Background Sensitivity: many vacuolated spaces within the seminiferous epithelia of tubules

abnormal seminiferous tubule epithelium morphology ( J:237048 )

♂ • Background Sensitivity: missing layers of spermatogenic cells, including basal spermatogonia or adluminal spermatocytes and spermatids

abnormal fertility/fecundity ( J:237048 )

♂ • Background Sensitivity: increase in the time between litters sired by knockout males

♂ • normal breeding behavior, average numbers of pups per litter and time to birth of first litter

cellular

decreased male germ cell number ( J:237048 )

♂ • Background Sensitivity: some mice, presumably those with more 129 strain background, had extremely low cauda sperm counts

oligozoospermia ( J:237048 )

♂ • Background Sensitivity: some mice, presumably those with more 129 strain background, had extremely low cauda sperm counts

increased male germ cell apoptosis ( J:237048 )

♂ • Background Sensitivity: many vacuolated spaces within the seminiferous epithelia of tubules

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:237048 )

♂ • Background Sensitivity: missing layers of spermatogenic cells, including basal spermatogonia or adluminal spermatocytes and spermatids