Phenotypes Associated with This Genotype

Genotype
MGI:5806786

• Allelic Composition: Gt(ROSA)26Sor^{tm4(CAG-hsb5)Nki}/Gt(ROSA)26Sor⁺; Tg(Mx1-cre)1Cgn/0; Tg(tetO-BCR/ABL1)2Dgt/0; TgTn(pb-sb-GrOnc)#aGsva/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:227558 )

• mice withdrawn from tetracycline and treated with polyinosine-polycyticylic acid (pIpC) show a median survival of 125.5 days

neoplasm

increased leukemia incidence ( J:227558 )

• 26% of mice treated with pIpC develop lymphoid acute leukemias

• 70% of mice treated with pIpC develop myeloid acute leukemias

• increase in infiltration of tissues with immature cells