Phenotypes Associated with This Genotype

Genotype
MGI:5806784

• Allelic Composition: Tg(Mx1-cre)1Cgn/0; Tg(Tal1-tTA)19Dgt/0; Tg(tetO-BCR/ABL1)2Dgt/0; TgTn(pb-sb-GrOnc)#aGsva/0
• Genetic Background: involves: C57BL/6 * CBA/J * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:227558 )

• median survival of 149 days

neoplasm

increased chronic myelocytic leukemia incidence ( J:227558 )

• all mice remain in the chronic phase of myeloid leukemia

hematopoietic system

increased leukocyte cell number ( J:227558 )

• upon withdrawal of tetracycline, mice develop moderate, but persistent (2-3 fold) increase of white blood counts

increased granulocyte number ( J:227558 )

• upon withdrawal of tetracycline, mice show marked expansion of the granulocyte compartment

immune system

increased leukocyte cell number ( J:227558 )

• upon withdrawal of tetracycline, mice develop moderate, but persistent (2-3 fold) increase of white blood counts

increased granulocyte number ( J:227558 )

• upon withdrawal of tetracycline, mice show marked expansion of the granulocyte compartment