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Phenotypes Associated with This Genotype
Genotype
MGI:5790964
Allelic
Composition
Myo5btm1.1Cle/Myo5btm1.1Cle
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5btm1.1Cle mutation (0 available); any Myo5b mutation (2 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Microvillus inclusion disease phenotype in Myo5btm1.1Cle/Myo5btm1.1Cle Tg(Vil1-cre/ERT2)23Syr/0 mice

digestive/alimentary system
• tamoxifen induced mice show intestinal crypt hyperplasia
• intercellular spaces between enterocytes are enlarged in tamoxifen induced mice
• PAS-positive vesicles (secretory granules) are seen in crypt enterocytes and at the crypt-villus transition of tamoxifen treated mice
• mature villus enterocytes show clusters of subapical vesicles, autolysosomes, and microvillus inclusions on day 4 after tamoxifen induction
• marker analysis indicates disturbed basolateral polarity of villus enterocytes in tamoxifen treated mice
• subapical accumulation of secretory granules precedes occurrence of microvillus inclusions
• intestines show a severe reduction to almost complete absence of apical microvilli on day 4 after tamoxifen induction
• tamoxifen treated mice exhibit fusion of intestinal villi
• mice show intestinal villus atrophy on day 4 after tamoxifen induction
• tamoxifen induced mice exhibit watery diarrhea

growth/size/body
• mice exhibit severe weight loss starting from day 3 after tamoxifen induction

homeostasis/metabolism
• tamoxifen induced mice exhibit dehydration

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
microvillus inclusion disease DOID:0060775 OMIM:251850
J:227079


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory