Phenotypes Associated with This Genotype

Genotype
MGI:5780554

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Errfi1)Jwj}/?; Pgr^tm2(cre)Lyd/Pgr⁺; Pten^tm1Hwu/Pten^tm1Hwu
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:218222 )

♀ • mice exhibit significantly increased survival time relative to mice that are homozygous for Pten^tm1Hwu and heterozygous for Pgr^tm2(cre)Lyd, with >50% of mice still viable at 64 weeks of age

♀ • mice do not die due to the development of endometrial cancer

reproductive system

endometrium hyperplasia ( J:218222 )

♀ • mice exhibit endometrial hyperplasia at 2 months but not at 3 months of age

♀ • however, endometrial adenocarcinoma with invasion into the myometrium is not observed due to inhibition of ERK1/2 phosphorylation

increased uterus weight ( J:218222 )

♀ • at 3 months of age, mice show a significantly reduced increase in uterine/body weight ratio relative to mice that are homozygous for Pten^tm1Hwu and heterozygous for Pgr^tm2(cre)Lyd

abnormal uterus physiology ( J:218222 )

♀ • at 2 months of age, mice show a significantly reduced uterine epithelial cell proliferation relative to mice that are homozygous for Pten^tm1Hwu and heterozygous for Pgr^tm2(cre)Lyd

neoplasm

increased papilloma incidence ( J:218222 )

♀ • mice develop vaginal papillomas