About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5551754
Allelic
Composition		 Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+
Tbx1tm1Bld/Tbx1tm6(cre)Bld
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Tbx1/GFP)Bem mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Tbx1tm1Bld mutation (1 available); any Tbx1 mutation (34 available)
Tbx1tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Failure of inner ear morphogenesis in Tbx1tm1Bld/Tbx1tm1Bld mice at E14.5 and partial rescue of inner ear morphogenesis in Tbx1tm6(cre)Bld/Tbx1tm1Bld Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/ Gt(ROSA)26Sor+ mice

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:204435 )
N
• recovery of the anterior and posterior semicircular canals compared with null mice
abnormal cochlea morphology ( J:204435 )
• partial rescue with null mice
abnormal vestibular saccule morphology ( J:204435 )
• partial rescue with null mice

cardiovascular system
double outlet right ventricle ( J:204435 )
• in half of mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory