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Phenotypes Associated with This Genotype
Genotype
MGI:5551754
Allelic
Composition		 Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+
Tbx1tm1Bld/Tbx1tm6(cre)Bld
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Tbx1/GFP)Bem mutation (1 available); any Gt(ROSA)26Sor mutation (1061 available)
Tbx1tm1Bld mutation (1 available); any Tbx1 mutation (36 available)
Tbx1tm6(cre)Bld mutation (1 available); any Tbx1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Failure of inner ear morphogenesis in Tbx1tm1Bld/Tbx1tm1Bld mice at E14.5 and partial rescue of inner ear morphogenesis in Tbx1tm6(cre)Bld/Tbx1tm1Bld Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/ Gt(ROSA)26Sor+ mice

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:204435 )
N
• recovery of the anterior and posterior semicircular canals compared with null mice
abnormal cochlea morphology ( J:204435 )
• partial rescue with null mice
abnormal vestibular saccule morphology ( J:204435 )
• partial rescue with null mice

cardiovascular system
double outlet right ventricle ( J:204435 )
• in half of mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory