Phenotypes Associated with This Genotype

Genotype
MGI:5524150

• Allelic Composition: Stk11^tm1.1Rdp/Stk11^tm1.1Rdp; Isl1^tm1(cre)Tmj/Isl1⁺
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:201695 )

• mice are euthanized at 4 to 6 weeks due to massive gastrointestinal tumors

• however, mice survive to birth and postnatally

neoplasm

increased gastrointestinal tumor incidence ( J:201695 )

• massive gastrointestinal tumors

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:201695 )

• massive gastrointestinal tumors

nervous system

nervous system phenotype ( J:201695 )

N • axon bundles are normal in the brainstem trigeminal complex, ascending tracts in the spinal cord (spinocerebellar, spinothalamic and dorsal funiculus), the optic nerve and motor and sensory nerves in the periphery

N • mice exhibit normal type Ia proprioceptive sensory neuron projections to the ventral horn

N • mice exhibit no sensory or motor deficit

abnormal cerebral cortex morphology ( J:201695 )

• axons tracts in the cortical intermediate zone are reduced compared to in control mice

thin cerebral cortex ( J:201695 )

• thin-walled

behavior/neurological

behavior/neurological phenotype ( J:201695 )

N • mice exhibit no sensory or motor deficit