Phenotypes Associated with This Genotype

Genotype
MGI:5486302

• Allelic Composition: \Cdc42^tm1Brak/\Cdc42^tm1Brak; \Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/\Six2⁺
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Kidney abnormalities in Cdc42^tm1Brak/Cdc42^tm1Brak Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ mice

mortality/aging

postnatal lethality, complete penetrance ( J:195266 )

renal/urinary system

abnormal kidney cortex morphology ( J:195266 )

• absence of convoluted renal epithelia and glomeruli in the cortex

decreased renal glomerulus number ( J:195266 )

• at P0

abnormal kidney development ( J:195266 )

• very limited nephrogenesis

abnormal nephrogenic zone morphology ( J:195266 )

• reduced nephrogenic zone at E18.5

abnormal kidney papilla morphology ( J:195266 )

• small papilla at E18.5

renal hypoplasia ( J:195266 )

• at P0

abnormal proximal convoluted tubule morphology ( J:195266 )

• tubules are decreased in number, truncated and have barely discernible lumens

decreased renal tubule number ( J:195266 )

• fewer proximal tubules

anuria ( J:195266 )

• neonatal mice have an empty bladder suggesting a failure to produce urine