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Phenotypes Associated with This Genotype
Genotype
MGI:5439657
Allelic
Composition
Bap1tm1.1Geno/Bap1tm1.1Geno
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background
involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bap1tm1.1Geno mutation (0 available); any Bap1 mutation (10 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (310 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• changes in leukocyte numbers are consistent with a chronic myelomonocytic leukemia (CMML)-like disease
• transplantation of bone marrow cells into lethally irradiated congenic wild-type mice followed by tamoxifen treatment also results in a CMML-like disease

hematopoietic system
• at 4 weeks after the last tamoxifen injection peripheral blood shows cytological features consistent with myelodysplasia
• increase in the number of lineage-negative ScaI? c-Kit+ myeloid progenitor cells in the spleen and bone marrow as early as 2 weeks after the last tamoxifen treatment
• atypical immature cells with myelomonocytic features detected after tamoxifen treatment
• expansion of the myeloid lineage in the spleen, lymph nodes and bone marrow at 4 weeks after the last tamoxifen injection
• 4 weeks after the last tamoxifen injection
• develop severe progressive anemia after tamoxifen treatment
• signs of erythroid dysplasia after tamoxifen treatment
• prominent basophilic stippling after tamoxifen treatment
• at 4 weeks after the last tamoxifen injection peripheral blood shows cytological features consistent with ineffective erythropoiesis
• after tamoxifen treatment
• after tamoxifen treatment
• bilobed granulocytes after tamoxifen treatment
• hypersegmented and hyposegmented neutrophils after tamoxifen treatment
• 4 weeks after the last tamoxifen injection
• detected as early as 1 week after the last tamoxifen treatment
• giant platelets detected after tamoxifen treatment
• elevated total leukocyte numbers at 4 weeks after the last tamoxifen injection
• 4 weeks after the last tamoxifen injection
• in the spleen and bone marrow as early as 2 weeks after the last tamoxifen treatment
• seen in all mice 4 weeks after the last tamoxifen injection
• cells taken from tamoxifen treated mice fail to reconstitute the bone marrow of lethally irradiated congenic wild-type mice
• cultured cells collected 1 month after the last tamoxifen treatment produce fewer colonies and replated cells do not produce well formed colonies

immune system
• neutrophilic inflammation and infiltration of myeloblastic cells after tamoxifen treatment
• at 4 weeks after the last tamoxifen injection peripheral blood shows cytological features consistent with myelodysplasia
• increase in the number of lineage-negative ScaI? c-Kit+ myeloid progenitor cells in the spleen and bone marrow as early as 2 weeks after the last tamoxifen treatment
• atypical immature cells with myelomonocytic features detected after tamoxifen treatment
• expansion of the myeloid lineage in the spleen, lymph nodes and bone marrow at 4 weeks after the last tamoxifen injection
• bilobed granulocytes after tamoxifen treatment
• hypersegmented and hyposegmented neutrophils after tamoxifen treatment
• 4 weeks after the last tamoxifen injection
• elevated total leukocyte numbers at 4 weeks after the last tamoxifen injection
• 4 weeks after the last tamoxifen injection
• seen in all mice 4 weeks after the last tamoxifen injection

homeostasis/metabolism
• microthrombi in the heart after tamoxifen treatment

muscle
• multifocal necrosis after tamoxifen treatment

cardiovascular system
• neutrophilic inflammation and infiltration of myeloblastic cells after tamoxifen treatment

Mouse Models of Human Disease
OMIM ID Ref(s)
Myelodysplastic Syndrome; MDS 614286 J:187380


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory