About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5432224
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(CYP19A1-cre)1Jri/0
Genetic
Background
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (27 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Tg(CYP19A1-cre)1Jri mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die within 3.5-5.5 months of age

neoplasm
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
• female mutants develop bilateral granulosa cell tumors by 3 months of age

endocrine/exocrine glands
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
• female mutants develop bilateral granulosa cell tumors by 3 months of age

reproductive system
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
• female mutants develop bilateral granulosa cell tumors by 3 months of age

homeostasis/metabolism
• at 6 weeks of age in females
• at 6 weeks of age in females
• at 6 weeks of age in females

cellular
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

Mouse Models of Human Disease
OMIM ID Ref(s)
Ovarian Cancer 167000 J:186144


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/12/2016
MGI 6.04
The Jackson Laboratory