About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5432224
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(CYP19A1-cre)1Jri/0
Genetic
Background
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (18 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Tg(CYP19A1-cre)1Jri mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die within 3.5-5.5 months of age (J:186144)
• mutants die within 3.5-5.5 months of age (J:186144)

tumorigenesis
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age (J:186144)
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age (J:186144)
• female mutants develop bilateral granulosa cell tumors by 3 months of age (J:186144)
• female mutants develop bilateral granulosa cell tumors by 3 months of age (J:186144)

endocrine/exocrine glands
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked (J:186144)
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked (J:186144)

reproductive system
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked (J:186144)
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked (J:186144)

homeostasis/metabolism
• at 6 weeks of age in females (J:186144)
• at 6 weeks of age in females (J:186144)
• at 6 weeks of age in females (J:186144)
• at 6 weeks of age in females (J:186144)
• at 6 weeks of age in females (J:186144)
• at 6 weeks of age in females (J:186144)
• at 6 weeks of age in females (J:186144)
• at 6 weeks of age in females (J:186144)

cellular
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked (J:186144)
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked (J:186144)

Mouse Models of Human Disease
OMIM ID Ref(s)
Ovarian Cancer 167000 J:186144


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory