Mouse Genome Informatics
cn
    Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(CYP19A1-cre)1Jri/0

involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die within 3.5-5.5 months of age

tumorigenesis
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
• female mutants develop bilateral granulosa cell tumors by 3 months of age

endocrine/exocrine glands
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

reproductive system
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

homeostasis/metabolism
• at 6 weeks of age in females
• at 6 weeks of age in females
• at 6 weeks of age in females

cellular
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

Mouse Models of Human Disease
OMIM IDRef(s)
Ovarian Cancer 167000 J:186144