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Phenotypes Associated with This Genotype
Genotype
MGI:4947942
Allelic
Composition		 Cd40lgtm1Flv/Y
Faslpr/Faslpr
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * MRL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgtm1Flv mutation (1 available); any Cd40lg mutation (12 available)
Faslpr mutation (39 available); any Fas mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:38492 )
• relative to mutant mice wild-type for Cd40lg

immune system
decreased immunoglobulin level ( J:38492 )
• lower titers of immunoglobulins compared to mutant mice wild-type for Cd40lg
decreased IgG level ( J:38492 )
• lower titers of IgG1, IgG2a dna IgG2b compared to mice homozygous for Faslpr and Cd40lgtm1Flv
decreased autoantibody level ( J:38492 )
• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg

integument
alopecia ( J:38492 )
• develop severe hair loss by 24 weeks of age
skin lesions ( J:38492 )
• develop scabs and purpuric lesions of the dorsal neck and ears by 24 weeks of age

renal/urinary system
abnormal kidney morphology ( J:38492 )
• substantial reduction in renal disease compared to mutant mice wild-type for Cd40lg

hematopoietic system
decreased immunoglobulin level ( J:38492 )
• lower titers of immunoglobulins compared to mutant mice wild-type for Cd40lg
decreased IgG level ( J:38492 )
• lower titers of IgG1, IgG2a dna IgG2b compared to mice homozygous for Faslpr and Cd40lgtm1Flv

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory