Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tcratm1Mjo
Name:	T cell receptor alpha chain; targeted mutation 1, Michael J Owen
MGI ID:	MGI:2180883
Synonyms:	Calpha-, Tcralpha-, TCRalpha, TCRalphae-, TCRalpha KO, Tcratm1Phi
Gene:	Tcra  Location: Chr14:52665424-54461655 bp, + strand  Genetic Position: Chr14, cytoband D1-D2

Germline Transmission:	Earliest citation of germline transmission: J:1292
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion     The Tcra-C element C1 was disrupted by the insertion of a neomycin selection cassette. (J:1292)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Tcra Mutation:	98 strains or lines available

Original:	J:1292 Philpott KL, et al., Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. Science. 1992 Jun 5;256(5062):1448-52
All:	106 reference(s)