Mouse Genome Informatics
cn
    Errfi1tm1Jwj/Errfi1tm1Jwj
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• survival time of double mutants is shorter than either single mutant, with mice dying by 16 weeks of age

reproductive system
• decrease in the number of apoptotic cells in the endothelium epithelium compared to single Pten mutants (J:162027)
• proliferation is increased in the endothelium epithelium (J:162027)
• mutants exhibit endometrial hyperplasia at 2 weeks of age and develop endometrial adenocarcinoma at 4 weeks of age (J:162027)
• however, myometrial hyperplasia is not observed in the uteri of mutants (J:162027)
• increase in uterine weight at 2 weeks of age, with weight at 4 weeks greater than in single Pten mutants (J:162027)

tumorigenesis
• mutants exhibit distant metastases into the ovary, diaphragmatic skeletal muscle, lymph node, colon and pancreas
• development of endometrial cancer is accelerated compared to either single mutant (J:162027)

Mouse Models of Human Disease
OMIM IDRef(s)
Endometrial Cancer 608089 J:162027