Phenotypes for Brca2 Tg(Pdx1-cre)6Tuv Trp53 MGI:4940104 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Brca2^tm1Cam/Brca2^tm1Brn Tg(Pdx1-cre)6Tuv/0 Trp53^tm3Tyj/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Brn mutation (3 available); any Brca2 mutation (131 available)
Brca2^tm1Cam mutation (0 available); any Brca2 mutation (131 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm3Tyj mutation (2 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

exocrine pancreatic insufficiency ( J:166678 )

• pancreatic insufficiency is occasionally observed in mutants

endocrine/exocrine glands

exocrine pancreatic insufficiency ( J:166678 )

• pancreatic insufficiency is occasionally observed in mutants

mortality/aging

premature death ( J:166678 )

• premature death before 600 days of age due to lymphoid malignancies and sarcomas

neoplasm

increased malignant tumor incidence ( J:166678 )

• mutants develop lymphoid malignancies

increased sarcoma incidence ( J:166678 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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