Phenotypes Associated with This Genotype

Genotype
MGI:4940102

• Allelic Composition: Brca2^tm1Cam/Brca2^tm1Brn; Kras^tm4Tyj/Kras⁺; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

exocrine pancreatic insufficiency ( J:166678 )

• pancreatic insufficiency; spectrum of anomalies are seen from isolated paucity of the islets of Langerhans to complete fibro-inflammatory or cystic degeneration of both the endocrine and exocrine pancreas

endocrine/exocrine glands

increased pancreas apoptosis ( J:166678 )

• pancreata from 6 day old mutants exhibits an increase in apoptotic cells compared to controls

exocrine pancreatic insufficiency ( J:166678 )

• pancreatic insufficiency; spectrum of anomalies are seen from isolated paucity of the islets of Langerhans to complete fibro-inflammatory or cystic degeneration of both the endocrine and exocrine pancreas

increased pancreatic ductal adenocarcinoma incidence ( J:166678 )

• mutants not succumbing to pancreatic insufficiency later develop pancreatic ductal adenocarcinomas with a moderate latency and incomplete penetrance (6 of 32 mutants)

mortality/aging

premature death ( J:166678 )

• mutants exhibit shortened pancreatic ductal adenocarcinoma-free survival

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:166678 )

• mutants not succumbing to pancreatic insufficiency later develop pancreatic ductal adenocarcinomas with a moderate latency and incomplete penetrance (6 of 32 mutants)

cellular

increased pancreas apoptosis ( J:166678 )

• pancreata from 6 day old mutants exhibits an increase in apoptotic cells compared to controls