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Phenotypes Associated with This Genotype
Genotype
MGI:4940099
Allelic
Composition		 Brca2tm1Cam/Brca2+
Krastm4Tyj/Kras+
Trp53tm3Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Cam mutation (0 available); any Brca2 mutation (131 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm3Tyj mutation (2 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• 26 of 30 mutants develop pancreatic ductal adenocarcinomas

mortality/aging
premature death ( J:166678 )
• average survival time is 143 days, with a range of 91-191 days

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• 26 of 30 mutants develop pancreatic ductal adenocarcinomas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory