Phenotypes Associated with This Genotype

Genotype
MGI:4868582

• Allelic Composition: Gfi1b^tm2Tmo/Gfi1b^tm2Tmo; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:167416 )

N • pIpC injection induces cre expression

abnormal blood cell morphology/development ( J:167416 )

decreased erythrocyte cell number ( J:167416 )

• in the peripheral blood

thrombocytopenia ( J:167416 )

• in peripheral blood

increased hematopoietic stem cell number ( J:167416 )

• increased frequency of hematopoietic stem cells in bone marrow, spleen, and peripheral blood

increased splenocyte number ( J:167416 )

• due to the expansion of erythroid progenitors

abnormal hematopoietic stem cell physiology ( J:167416 )

• increased apoptosis but still below 2.5%

• increased levels of reactive oxygen species

immune system

increased splenocyte number ( J:167416 )

• due to the expansion of erythroid progenitors