Phenotypes Associated with This Genotype

Genotype
MGI:4839051

• Allelic Composition: Fas^lpr/Fas^lpr; Il4^tm1Cgn/Il4^tm1Cgn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal spleen size ( J:39600 )

• lympadenopathy (based on spleen weight and cellularity) is reduced compared to mice homozygous for Fas^lpr and wild-type for Il4

enlarged spleen ( J:39600 )

increased spleen weight ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4

spleen hyperplasia ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased immunoglobulin level ( J:39600 )

decreased IgA level ( J:39600 )

• at 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgE level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgG1 level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgG3 level ( J:39600 )

• at 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

abnormal lymph node size ( J:39600 )

• lympadenopathy (based on lymph node weight and cellularity) is reduced compared to mice homozygous for Fas^lpr and wild-type for Il4

decreased susceptibility to systemic lupus erythematosus ( J:39600 )

• while mice develop the typical autoimmune lesions end organ disease is decreased compared to mice homozygous for Fas^lpr and wild-type for Ifng

• incidence of end organ disease is increased compared to wild-type controls

decreased anti-nuclear antigen antibody level ( J:39600 )

• decrease in the percentage of FANA positive sera compared to controls at 3 months of age

• however, no significant differences in anti-dsDNA or anti-snRNP autoantibody levels are detected

homeostasis/metabolism

decreased circulating creatinine level ( J:39600 )

• levels are lower compared to mice homozygous for Fas^lpr and wild-type for Il4

hematopoietic system

abnormal spleen size ( J:39600 )

• lympadenopathy (based on spleen weight and cellularity) is reduced compared to mice homozygous for Fas^lpr and wild-type for Il4

enlarged spleen ( J:39600 )

increased spleen weight ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4

spleen hyperplasia ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased immunoglobulin level ( J:39600 )

decreased IgA level ( J:39600 )

• at 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgE level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgG1 level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

decreased IgG3 level ( J:39600 )

• at 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Il4

growth/size/body

enlarged spleen ( J:39600 )

increased spleen weight ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4

spleen hyperplasia ( J:39600 )

• relative to wild-type controls but decreased relative to mice homozygous for Fas^lpr and wild-type for Il4