Phenotypes Associated with This Genotype

Genotype
MGI:4839049

• Allelic Composition: Fas^lpr/Fas^lpr; Ifng^tm1Ts/Ifng^tm1Ts
• Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased double-negative T cell number ( J:39600 )

• decrease in the number of CD4-CD8-B220+ alpha beta T cells compared to mice homozygous for Fas^lpr and wild-type for Ifng

abnormal spleen size ( J:39600 )

• lympadenopathy (based on spleen weight and cellularity) is reduced compared to mice homozygous for Fas^lpr and wild-type for Ifng

enlarged spleen ( J:39600 )

• at 7-8 months of age a modest increase in spleen size and cellularity is seen relative to wild-type controls

decreased immunoglobulin level ( J:39600 )

decreased IgA level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Ifng

decreased IgG2a level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Ifng

decreased IgG2b level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Ifng

decreased IgM level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Ifng

abnormal lymph node size ( J:39600 )

• lympadenopathy (based on lymph node weight and cellularity) is reduced compared to mice homozygous for Fas^lpr and wild-type for Ifng

• in young animals lymph node size is similar to wild-type controls

enlarged lymph nodes ( J:39600 )

• at 7-8 months of age a modest increase in lymph node size and cellularity is seen relative to wild-type controls

decreased susceptibility to systemic lupus erythematosus ( J:39600 )

• while mice develop the typical autoimmune lesions, end organ disease is decreased compared to mice homozygous for Fas^lpr and wild-type for Ifng

decreased autoantibody level ( J:39600 )

• lower titers of anti-snRNP and anti-rheumatoid factors antibodies relative to mice homozygous for Fas^lpr and wild-type for Ifng at 3 and 7-8 months of age

decreased anti-nuclear antigen antibody level ( J:39600 )

• at 3 and 7-8 months of age

decreased anti-double stranded DNA antibody level ( J:39600 )

• at 3 and 7-8 months of age

homeostasis/metabolism

decreased circulating creatinine level ( J:39600 )

• levels are lower compared to mice homozygous for Fas^lpr and wild-type for Ifng

hematopoietic system

decreased double-negative T cell number ( J:39600 )

• decrease in the number of CD4-CD8-B220+ alpha beta T cells compared to mice homozygous for Fas^lpr and wild-type for Ifng

abnormal spleen size ( J:39600 )

• lympadenopathy (based on spleen weight and cellularity) is reduced compared to mice homozygous for Fas^lpr and wild-type for Ifng

enlarged spleen ( J:39600 )

• at 7-8 months of age a modest increase in spleen size and cellularity is seen relative to wild-type controls

decreased immunoglobulin level ( J:39600 )

decreased IgA level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Ifng

decreased IgG2a level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Ifng

decreased IgG2b level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Ifng

decreased IgM level ( J:39600 )

• at 3 and 7-8 months of age relative to mice homozygous for Fas^lpr and wild-type for Ifng

growth/size/body

enlarged spleen ( J:39600 )

• at 7-8 months of age a modest increase in spleen size and cellularity is seen relative to wild-type controls