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Phenotypes Associated with This Genotype
Genotype
MGI:4818943
Allelic
Composition
Tg(CD2-Stat6*V625A*T626A)78Mhk/0
Genetic
Background
involves: C3H * C57BL/6
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• resulting in alopecia on the face, back, and other areas

homeostasis/metabolism
• 10 days after retinoic acid treatment, mice exhibit a 4-fold elevation in transepithelial water loss unlike similarly treated wild-type mice

immune system
• mice develop skin inflammation that is similar to atopic dermatitis unlike wild-type mice

integument
• 10 days after retinoic acid treatment, mice exhibit a 4-fold elevation in transepithelial water loss unlike similarly treated wild-type mice
• mice develop skin inflammation that is similar to atopic dermatitis unlike wild-type mice
• on the face, back, and other areas secondary to excessive scratching
• eosinophils and lymphocytes

Mouse Models of Human Disease
OMIM ID Ref(s)
Dermatitis, Atopic 603165 J:160119


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory