Phenotypes Associated with This Genotype

Genotype
MGI:4462259

• Allelic Composition: Il4^tm1Kopf/Il4^tm1Kopf; Lyn^tm1Ard/Lyn^tm1Ard
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased basophil cell number ( J:161523 )

increased mast cell number ( J:161523 )

• in the peritoneum

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

decreased IgE level ( J:161523 )

decreased IgG1 level ( J:161523 )

increased IgG2a level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

immune system

increased basophil cell number ( J:161523 )

increased mast cell number ( J:161523 )

• in the peritoneum

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

decreased IgE level ( J:161523 )

decreased IgG1 level ( J:161523 )

increased IgG2a level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

increased anti-nuclear antigen antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

increased anti-double stranded DNA antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q