Phenotypes Associated with This Genotype

Genotype
MGI:4457262

• Allelic Composition: T/t^btm
• Genetic Background: involves: C57BL/6 * MOL-NIS

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal rostral-caudal body axis extension ( J:21054 )

• attenuated development of the posterior part of the body

abnormal neural tube morphology ( J:21054 )

• generally distorted, duplicated or fused with the mesenchyme

meningomyelocele ( J:21054 )

• presents as a dorsal blood blister in the lumbosacral region

abnormal notochord morphology ( J:21054 )

• E11-12 embryos show abnormalities in the medio-dorsal area

notochord degeneration ( J:21054 )

• seen in E11-12 embryos

split notochord ( J:21054 )

• seen in E11-12 embryos

abnormal tail bud morphology ( J:21054 )

• at E10 a constriction occurs as the tail develops

nervous system

abnormal neural tube morphology ( J:21054 )

• generally distorted, duplicated or fused with the mesenchyme

meningomyelocele ( J:21054 )

• presents as a dorsal blood blister in the lumbosacral region

abnormal spinal cord morphology ( J:21054 )

• posterior to the lumbosacral level the cord is severely distorted or duplicated and devoid of vertebrae

limbs/digits/tail

absent caudal vertebrae ( J:21054 )

abnormal tail development ( J:21054 )

abnormal tail bud morphology ( J:21054 )

• at E10 a constriction occurs as the tail develops

absent tail ( J:21054 )

• mice with this genotype lack a tail at birth and have blood listers or red scars on the dorsal skin at the middle of the lumbosacral region

skeleton

meningomyelocele ( J:21054 )

• presents as a dorsal blood blister in the lumbosacral region

absent caudal vertebrae ( J:21054 )

abnormal thoracic vertebrae morphology ( J:21054 )

• rib fusions, lack of vertebral bodies and arches

abnormal lumbar vertebrae morphology ( J:21054 )

• rib fusions, lack of vertebral bodies and arches

absent sacral vertebrae ( J:21054 )

absent vertebral arch ( J:21054 )

• an abnormality of thoracic and lumbar vertebrae

absent vertebral body ( J:21054 )

• an abnormality of thoracic and lumbar vertebrae

absent vertebrae ( J:21054 )