Phenotypes Associated with This Genotype

Genotype
MGI:4454418

• Allelic Composition: Sox11^tm1Weg/Sox11^tm1Weg; Sox4^tm1Vlf/Sox4^tm1Vlf; Tg(Dbh-icre)1Gsc/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal sympathetic ganglion morphology ( J:157923 )

• sympathetic ganglia are significantly smaller and have fewer cells at E11.5, E14.5 and E18.5

abnormal nervous system development ( J:157923 )

• expression analysis indicates a delay in noradrenergic differentiation in the sympathetic ganglia

• sympathetic ganglia are almost devoid of proliferating cells at E11.5 and have a dramatic reduction at E12.5 but by E14.5 the absolute number of BrdU-labeled cells is only slightly lower than in the wild-type when corrected for the decrease in size of the sympathetic ganglia, proliferation is increased relative to wild-type at E14.5 and E16.5

• the number of apoptotic cells in the sympathetic ganglia is increased 2.5 to 4 fold at E14.5 and E16.5r of apoptotic cells in the sympathetic ganglia is increased 2.5 to 4 fold at E14.5 and E16.5