Phenotypes Associated with This Genotype

Genotype
MGI:4443009

• Allelic Composition: Dok1^tm1Ppp/Dok1^tm1Ppp; Dok2^tm1Ppp/Dok2^tm1Ppp; Dok3^tm1Ppp/Dok3^tm1Ppp
• Genetic Background: 129S1/Sv-Dok1^tm1Ppp Dok2^tm1Ppp Dok3^tm1Ppp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:158011 )

• mice begin to die at around 1 year of age unlike wild-type mice

respiratory system

pulmonary hyperplasia ( J:158011 )

• mice exhibit an increase in the total number of lung cells compared with wild-type mice

• however, lung weight is normal

increased lung tumor incidence ( J:158011 )

• at 6 weeks, 30% of mice develop small lung tumors unlike wild-type mice

increased lung adenocarcinoma incidence ( J:158011 )

• at 11-25 months, 64% of mice develop lung adenocarcinoma compared with 7% of wild-type mice

increased bronchioalveolar stem cell number ( J:158011 )

• the number and percentages of bronchioalveolar stem cells are increased compared to in wild-type mice

abnormal pulmonary alveolus morphology ( J:158011 )

• at 12 weeks, mice exhibit alveolar hyperplasia with scattered bronchioaveolar stem cells unlike in wild-type mice

increased type II pneumocyte number ( J:158011 )

• the number and percentages of alveolar type 2 cells are increased compared to in wild-type mice

neoplasm

increased chronic myelocytic leukemia incidence ( J:158011 )

• at 20 months, mice exhibit an expansion of Mac-1+ and GR-1+ Mac-1+ cells compared with wild-type mice

• however, Mac-1+ and GR-1+ Mac-1+ cell numbers are normal at 3 months

increased lung tumor incidence ( J:158011 )

• at 6 weeks, 30% of mice develop small lung tumors unlike wild-type mice

increased lung adenocarcinoma incidence ( J:158011 )

• at 11-25 months, 64% of mice develop lung adenocarcinoma compared with 7% of wild-type mice

immune system

increased leukocyte cell number ( J:158011 )

• after 18 months

hematopoietic system

increased leukocyte cell number ( J:158011 )

• after 18 months

growth/size/body

pulmonary hyperplasia ( J:158011 )

• mice exhibit an increase in the total number of lung cells compared with wild-type mice

• however, lung weight is normal