Analysis Tools
vision/eye
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• some eyes are atrophic and phthisical unlike in wild-type mice
• at 6 months, 75% of mice exhibit enlarged eyes compared with wild-type mice
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• at 15 and 30 weeks
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• at 10, 15, and 30 weeks
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• as early as 18 days, some mice exhibit closed iridocorneal angles unlike wild-type mice
• at 7 weeks, 50% of mice exhibit closed iridocorneal angles unlike wild-type mice
• at 12 to 16 weeks, 80% of mice exhibit closed iridocorneal angles unlike wild-type mice
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• between 18 days and 16 weeks, some mice exhibit peripheral anterior synechiae unlike wild-type mice
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buphthalmos
(
J:158008
)
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• beginning at 6 to 12 weeks unilaterally then spreading bilaterally over the next 1 to 2 months with continued enlargement until 6 months of age
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• 6 weeks, mice exhibit increased intraocular pressure compared with wild-type mice that increases further by 10 weeks of age
• mice with increased intraocular pressure exhibit closed iridocorneal angles
• however, treatment with ocular hypotensives such as latanoprost, dorzolamide and timolol produces a greater reduction in intraocular pressure than in similarly treated wild-type mice
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homeostasis/metabolism
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• treatment with Y27632 fails to lower intraocular pressure unlike in wild-type mice
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• treatment with ocular hypotensives such as latanoprost, dorzolamide and timolol produces a greater reduction in intraocular pressure than in similarly treated wild-type mice
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nervous system
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• at 15 and 30 weeks
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• at 10, 15, and 30 weeks
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