Phenotypes Associated with This Genotype

Genotype
MGI:4420943

• Allelic Composition: Atoh1^tm3Hzo/Atoh1⁺; Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}
• Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal precursor proliferation ( J:155047 )

• ectopic masses show numerous mitotic granule neuron precursors 10 days after tamoxifen treatment

abnormal cerebellum morphology ( J:155047 )

• 10 days after tamoxifen treatment, neoplastic and preneoplastic lesions in which the external granule layer lacks the normal layered structure develop in the external layer of the cerebellum

abnormal cerebellum external granule cell layer morphology ( J:155047 )

• hypertrophic 10 days after tamoxifen treatment

irregular external granule cell layer thickness ( J:155047 )

• 10 days after tamoxifen treatment, neoplastic and preneoplastic lesions in which the external granule layer lacks the normal layered structure develop in the external layer of the cerebellum

cellular

abnormal neuronal precursor proliferation ( J:155047 )

• ectopic masses show numerous mitotic granule neuron precursors 10 days after tamoxifen treatment