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Phenotypes Associated with This Genotype
Genotype
MGI:4420935
Allelic
Composition		 Atoh1tm3Hzo/Atoh1tm1Hzo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic
Background		 involves: 129 * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh1tm1Hzo mutation (0 available); any Atoh1 mutation (36 available)
Atoh1tm3Hzo mutation (1 available); any Atoh1 mutation (36 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal precursor proliferation ( J:155047 )
• no cycling granule neuron precursor cells are detected in the external granule cell layer 10 days after tamoxifen treatment
thin external granule cell layer ( J:155047 )
• 10 days after tamoxifen treatment
cerebellum atrophy ( J:155047 )
• 10 days after tamoxifen treatment most mice have atrophic cerebella

cellular
abnormal neuronal precursor proliferation ( J:155047 )
• no cycling granule neuron precursor cells are detected in the external granule cell layer 10 days after tamoxifen treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory