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Phenotypes Associated with This Genotype
Genotype
MGI:4411991
Allelic
Composition		 Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Stk3tm1Jav mutation (0 available); any Stk3 mutation (47 available)
Stk4Gt(AJ0315)Wtsi mutation (0 available); any Stk4 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver hyperplasia ( J:153945 )
• develop massively overgrown livers by 3 months of age (4 out of 4)
increased hepatocellular carcinoma incidence ( J:153945 )
• develop hepatocellular carcinomas (HHCs) by 3 months of age (4 out of 4)

neoplasm
increased hepatocellular carcinoma incidence ( J:153945 )
• develop hepatocellular carcinomas (HHCs) by 3 months of age (4 out of 4)

growth/size/body
liver hyperplasia ( J:153945 )
• develop massively overgrown livers by 3 months of age (4 out of 4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory