Phenotypes for Pkd1 Tg(Nes-cre)1Kln MGI:4366028 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Pkd1^tm2.2Bol/Pkd1^tm3.1Bol Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1^tm2.2Bol mutation (0 available); any Pkd1 mutation (153 available)
Pkd1^tm3.1Bol mutation (0 available); any Pkd1 mutation (153 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hydrocephalus in Pkd1^tm2.2Bol/Pkd1^tm3.1Bol Tg(Nes-cre)1Kln/0 mice

mortality/aging

postnatal lethality, complete penetrance ( J:153606 )

• around P12

nervous system

hydrocephaly ( J:153606 )

• at P8

abnormal brain ventricle morphology ( J:153606 )

• at P10, mice exhibit a triventricular phenotype unlike wild-type mice

dilated lateral ventricle ( J:153606 )

dilated third ventricle ( J:153606 )

• at P8

renal/urinary system

kidney cyst ( J:153606 )

kidney failure ( J:153606 )

growth/size/body

kidney cyst ( J:153606 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/28/2026 MGI 6.24