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Phenotypes Associated with This Genotype
Genotype
MGI:4360749
Allelic
Composition		 Ext1tm1Yama/Ext1+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tgfb2tm1Doe/Tgfb2+
Genetic
Background		 B6.Cg-Tgfb2tm1Doe H2az2Tg(Wnt1-cre)11Rth Ext1tm1Yama
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ext1tm1Yama mutation (0 available); any Ext1 mutation (65 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Tgfb2tm1Doe mutation (2 available); any Tgfb2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Thin cornea and iridocorneal dysgenesis in Ext1tm1Yama/Ext1+ H2az2Tg(Wnt1-cre)11Rth/0 Tgfb2tm1Doe/Tgfb2+ mice

mortality/aging
mortality/aging ( J:152572 )
N
• mice survive into adulthood

vision/eye
abnormal aqueous drainage system morphology ( J:152572 )
• mice exhibit defects in components of the aqueous drainage system
• however, the iridocorneal angle is normal
abnormal trabecular meshwork morphology ( J:152572 )
• the trabecular beam contains fewer cells than in wild-type mice
ocular hypertension ( J:152572 )
• mice exhibit ocular hypertension unlike single heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory