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Phenotypes Associated with This Genotype
Genotype
MGI:4358370
Allelic
Composition		 Itgavtm1Blb/Itgavtm1Blb
Itgb1tm1Ref/Itgb1tm1Ref
Itgb2tm2Bay/Itgb2tm2Bay
Itgb7tm1Cgn/Itgb7tm1Cgn
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgavtm1Blb mutation (0 available); any Itgav mutation (53 available)
Itgb1tm1Ref mutation (0 available); any Itgb1 mutation (59 available)
Itgb2tm2Bay mutation (3 available); any Itgb2 mutation (49 available)
Itgb7tm1Cgn mutation (3 available); any Itgb7 mutation (72 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:134784 )
N
• following pIpC-induction, dendritic cells transplanted into the footpad exhibit normal drainage into lymph nodes
abnormal cellular extravasation ( J:134784 )
• abolished in pIpC-induced mice
abnormal dendritic cell physiology ( J:134784 )
• following pIpC-induction, dendritic cells fail to adhere to and migrate on a 2-D substrate unlike wild-type dendritic cells
• however, dendritic cells from pIpC-induced mice exhibit normal migration in 3D matrix

cellular
abnormal cellular extravasation ( J:134784 )
• abolished in pIpC-induced mice

hematopoietic system
abnormal cellular extravasation ( J:134784 )
• abolished in pIpC-induced mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory