Itgav^tm1Blb
Targeted Allele Detail

Summary

• Symbol: Itgav^tm1Blb
• Name: integrin alpha V; targeted mutation 1, Bernhard L Bader
• MGI ID: MGI:3790236
• Synonyms: alphav^flox
• Gene: Itgav Location: Chr2:83554796-83637261 bp, + strand Genetic Position: Chr2, 49.33 cM
• Alliance: Itgav^tm1Blb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134784
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. Transient flp expression in ES cells was used to remove the neo cassette leaving exon 1 floxed. (J:134784)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgav Mutation: 53 strains or lines available

References

• Original: J:134784 Lammermann T, et al., Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature. 2008 May 1;453(7191):51-5
• All: 2 reference(s)