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Phenotypes Associated with This Genotype
Genotype
MGI:4357767
Allelic
Composition
Tg(Vav1-NUP98/HOXD13)G2Apla/0
Genetic
Background
C57BL/6-Tg(Vav1-NUP98/HOXD13)G2Apla
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vav1-NUP98/HOXD13)G2Apla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals develop leukemia, myelodysplastic syndrome, or some hematologic abnormality by 14 months

hematopoietic system
• peripheral blood cytopenias and dysplasia are observed in clinically healthy mutants at 4 to 7 months
• circulating nucleated red blood cells are seen seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• hypersegmented neutrophils are seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• observed in clinically healthy mutants at 4 to 7 months
• observed in clinically healthy mutants at 4 to 7 months
• observed in clinically healthy mutants at 4 to 7 months

immune system
• hypersegmented neutrophils are seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• observed in clinically healthy mutants at 4 to 7 months
• observed in clinically healthy mutants at 4 to 7 months
• observed in clinically healthy mutants at 4 to 7 months

neoplasm
• hematologic abnormalities progress to acute leukemia in a subset of mutants
• some animals develop myeloid leukemia with others developing undifferentiated leukemia characterized by hepatosplenic infiltration of blasts; a few animals develop precursor-T lymphoblastic lymphoma/leukemia (pre-T LBL)
• other mutants develop a myeloproliferative disease-like leukemia with one showing a biphenotypic leukemia with thymic enlargement and hepatosplenomegaly

Mouse Models of Human Disease
OMIM ID Ref(s)
Myelodysplastic Syndrome; MDS 614286 J:107446


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory