Mouse Genome Informatics
tg
    Tg(Vav1-NUP98/HOXD13)G2Apla/0
C57BL/6-Tg(Vav1-NUP98/HOXD13)G2Apla
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• animals develop leukemia, myelodysplastic syndrome, or some hematologic abnormality by 14 months

hematopoietic system
• peripheral blood cytopenias and dysplasia are observed in clinically healthy mutants at 4 to 7 months
• circulating nucleated red blood cells are seen seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• observed in clinically healthy mutants at 4 to 7 months
• observed in clinically healthy mutants at 4 to 7 months
• hypersegmented neutrophils are seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• observed in clinically healthy mutants at 4 to 7 months

immune system
• observed in clinically healthy mutants at 4 to 7 months
• observed in clinically healthy mutants at 4 to 7 months
• hypersegmented neutrophils are seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome
• observed in clinically healthy mutants at 4 to 7 months

tumorigenesis
• hematologic abnormalities progress to acute leukemia in a subset of mutants
• some animals develop myeloid leukemia with others developing undifferentiated leukemia characterized by hepatosplenic infiltration of blasts; a few animals develop precursor-T lymphoblastic lymphoma/leukemia (pre-T LBL)
• other mutants develop a myeloproliferative disease-like leukemia with one showing a biphenotypic leukemia with thymic enlargement and hepatosplenomegaly

Mouse Models of Human Disease
OMIM IDRef(s)
Myelodysplastic Syndrome; MDS 614286 J:107446