Phenotypes Associated with This Genotype

Genotype
MGI:4355990

• Allelic Composition: Kif7^maki/Kif7^maki; Ptch1^tm1Mps/Ptch1^tm1Mps; Tg(Hlxb9-GFP)1Tmj/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:151965 )

• compound mutants develop until E10.5, unlike Ptch1 single mutants that arrest at about E9.0

nervous system

abnormal neural tube morphology ( J:151965 )

• ventral cell types are expanded to encompass about 3/4 of the neural plate

• this expansion is less than that seen in Ptch1 single mutants

embryo

abnormal neural tube morphology ( J:151965 )

• ventral cell types are expanded to encompass about 3/4 of the neural plate

• this expansion is less than that seen in Ptch1 single mutants