Phenotypes for Creb1 Crem Tg(Dbh-icre)1Gsc MGI:4355664 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Creb1^tm3Gsc/Creb1^tm3Gsc Crem^tm1Gsc/Crem^tm1Gsc Tg(Dbh-icre)1Gsc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1^tm3Gsc mutation (2 available); any Creb1 mutation (59 available)
Crem^tm1Gsc mutation (0 available); any Crem mutation (40 available)
Tg(Dbh-icre)1Gsc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:121244 )

N	• mice survive birth and do not show reduced lifespans unlike lethality observed in Creb1-germline null mice

nervous system

decreased neuron apoptosis ( J:121244 )

• at E17.5 reduced numbers of apoptotic cells are observed compared to controls Creb1^tm1Gsc null mice

abnormal superior cervical ganglion morphology ( J:121244 )

• numbere of SCG neurons is increased compared to controls at E17.5

cellular

decreased neuron apoptosis ( J:121244 )

• at E17.5 reduced numbers of apoptotic cells are observed compared to controls Creb1^tm1Gsc null mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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