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Phenotypes Associated with This Genotype
Genotype
MGI:4355664
Allelic
Composition		 Creb1tm3Gsc/Creb1tm3Gsc
Cremtm1Gsc/Cremtm1Gsc
Tg(Dbh-icre)1Gsc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1tm3Gsc mutation (2 available); any Creb1 mutation (59 available)
Cremtm1Gsc mutation (0 available); any Crem mutation (38 available)
Tg(Dbh-icre)1Gsc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:121244 )
N
• mice survive birth and do not show reduced lifespans unlike lethality observed in Creb1-germline null mice

nervous system
decreased neuron apoptosis ( J:121244 )
• at E17.5 reduced numbers of apoptotic cells are observed compared to controls Creb1tm1Gsc null mice
abnormal superior cervical ganglion morphology ( J:121244 )
• numbere of SCG neurons is increased compared to controls at E17.5

cellular
decreased neuron apoptosis ( J:121244 )
• at E17.5 reduced numbers of apoptotic cells are observed compared to controls Creb1tm1Gsc null mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory