Mouse Genome Informatics
hm
    Ccr2tm1Mae/Ccr2tm1Mae
B6.129P2-Ccr2tm1Mae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice
• at 16 months, mice exhibit attenuation of the retinal pigmented epithelium unlike in wild-type mice
• at 16 months, mice exhibit progressive outer retinal degeneration and confluent areas of visible atrophy unlike in wild-type mice
• at 18 months, mice exhibit geographic atrophy unlike in wild-type mice
• after 9 months of age, mice exhibit subretinal deposits similar to drusen that increase with age unlike in wild-type mice
• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice
• at 16 months, mice exhibit dilation and attenuation of the choriocapillaris unlike wild-type mice
• at 15 to 19 months, mice exhibit intrachoroidal neovascularization with angiographic leakage unlike wild-type mice
• after 18 months, 3 of 13 mice exhibit choroidal neovascularization with angiographic leakage unlike in wild-type mice
• between 18 and 27 months, neovasculatization breaches the Bruch membrane and causes retinal pigmented epithelium and photoreceptor disruptions unlike in wild-type mice
• the Bruch membrane is thickened compared to in wild-type mice after 9 months of age
• at 20 months, the outer Bruch membrane is breached by choriocapillary processes unlike in wild-type mice

behavior/neurological
• mice exhibit decreased preference for ethanol water compared with wild-type mice
• female mice exhibit a lesser ethanol preference compared with Ccl2tm1Rol Ccr2tm1Mae double homozygotes
• mice exhibit increased drinking of a quinine solution compared with wild-type mice
• mice exhibit increased drinking of an ethanol solution compared with wild-type mice and Ccl2tm1Rol Ccr2tm1Mae double homozygotes (J:102583)
• mice develop a stronger ethanol-induced conditioned taste aversion compared with similarly treated wild-type mice

immune system
• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice
• at 16 months, IgG is present in the retinal pigmented epithelium or choroids unlike in wild-type mice
• IgG light chain deposition in the retinal pigmented epithelium accumulates with age unlike in wild-type mice

cardiovascular system
• at 16 months, mice exhibit dilation and attenuation of the choriocapillaris unlike wild-type mice
• at 15 to 19 months, mice exhibit intrachoroidal neovascularization with angiographic leakage unlike wild-type mice
• after 18 months, 3 of 13 mice exhibit choroidal neovascularization with angiographic leakage unlike in wild-type mice
• between 18 and 27 months, neovasculatization breaches the Bruch membrane and causes retinal pigmented epithelium and photoreceptor disruptions unlike in wild-type mice

nervous system

pigmentation
• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice
• at 16 months, mice exhibit attenuation of the retinal pigmented epithelium unlike in wild-type mice
• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice

hematopoietic system
• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice
• at 16 months, IgG is present in the retinal pigmented epithelium or choroids unlike in wild-type mice
• IgG light chain deposition in the retinal pigmented epithelium accumulates with age unlike in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Macular Degeneration, Age-Related, 2; ARMD2 153800 J:147328