Phenotypes Associated with This Genotype

Genotype
MGI:3815535

• Allelic Composition: Tg(KRT5-rtTA)1Glk/0; Tg(tetO-TGFB1*C223S*C225S)1Glk/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:70670 )

N • double-transgenic mice with normal morphology are born at expected ratios when no doxycycline treatment is given to the dam

immune system

skin inflammation ( J:70670 )

• epidermis of weaning-aged mice dosed with doxycycline displays a variable neutrophilic infiltrate characterized by microabcesses within and above cornified layers

dermatitis ( J:70670 )

• weaning-aged mice dosed with doxycycline develop dermatitis on scalp and shoulders, as well as ventral surface, within 3-4 weeks; dermatitis extends caudally with time

cellular

increased keratinocyte apoptosis ( J:70670 )

• treatment with doxycycline induces keratinocyte apoptosis

abnormal cell proliferation ( J:70670 )

• cell proliferation in hyperplastic dermis of doxycycline-treated animals is elevated

decreased cell proliferation ( J:70670 )

• when adult mice undergo depilation and receive doxycycline treatment, cell proliferation is significantly reduced compared to mice which receive no doxycycline or single-transgenic controls

integument

increased keratinocyte apoptosis ( J:70670 )

• treatment with doxycycline induces keratinocyte apoptosis

skin inflammation ( J:70670 )

• epidermis of weaning-aged mice dosed with doxycycline displays a variable neutrophilic infiltrate characterized by microabcesses within and above cornified layers

dermatitis ( J:70670 )

• weaning-aged mice dosed with doxycycline develop dermatitis on scalp and shoulders, as well as ventral surface, within 3-4 weeks; dermatitis extends caudally with time

progressive hair loss ( J:70670 )

• weaning-aged mice dosed with doxycycline display progressive hair loss within 3-4 weeks

abnormal hair follicle morphology ( J:70670 )

• in weaning-aged mice dosed with doxycycline, many hair follicles appear hyperplastic with abnormal morphologies

• in animals treated with doxycycline, nearly all hair follicles have proliferating cells in the outer root sheath particularly in the infundibular region

decreased hair follicle number ( J:70670 )

• hair follicle density is significantly reduced in weaning-aged mice dosed with doxycycline

abnormal hair cycle ( J:70670 )

• treatment of animals with doxycycline causes keratinocytes to undergo growth arrest

dermal hyperplasia ( J:70670 )

• increased cellularity is observed in weaning-aged mice dosed with doxycycline

thick dermal layer ( J:70670 )

• significant thickening is observed in weaning-aged mice dosed with doxycycline

hyperkeratosis ( J:70670 )

• weaning-aged mice dosed with doxycycline develop hyperkeratosis within 3-4 weeks

acanthosis ( J:70670 )

• epidermis of affected mice (weanlings treated with doxycycline) becomes acanthotic

epidermal hyperplasia ( J:70670 )

• epidermis of affected mice (weanlings treated with doxycycline) exhibits hyperplasia