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Phenotypes Associated with This Genotype
Genotype
MGI:3804216
Allelic
Composition
Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brd/Trp53tm1Brd
Tg(Gfap-cre)2Brn/0
Genetic
Background
involves: 129 * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (3 available); any Rb1 mutation (106 available)
Tg(Gfap-cre)2Brn mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mutants develop highly aggressive embryonal tumors of the cerebellum with typical features of medulloblastoma
• tumors are identified as early as 7 weeks of age on the outer surface of the molecular layer, corresponding to the location of the cerebellar external granular layer cells during development

behavior/neurological
• loss of balance
• mutants hold their heads to one side
• gait is disturbed with ataxia

nervous system
• mutants develop highly aggressive embryonal tumors of the cerebellum with typical features of medulloblastoma
• tumors are identified as early as 7 weeks of age on the outer surface of the molecular layer, corresponding to the location of the cerebellar external granular layer cells during development

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:61961


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory