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Phenotypes Associated with This Genotype
Genotype
MGI:3804216
Allelic
Composition
Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brd/Trp53tm1Brd
Tg(Gfap-cre)2Brn/0
Genetic
Background
involves: 129 * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (3 available); any Rb1 mutation (78 available)
Tg(Gfap-cre)2Brn mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants develop highly aggressive embryonal tumors of the cerebellum with typical features of medulloblastoma
• tumors are identified as early as 7 weeks of age on the outer surface of the molecular layer, corresponding to the location of the cerebellar external granular layer cells during development

neoplasm
• mutants develop highly aggressive embryonal tumors of the cerebellum with typical features of medulloblastoma
• tumors are identified as early as 7 weeks of age on the outer surface of the molecular layer, corresponding to the location of the cerebellar external granular layer cells during development

behavior/neurological
• loss of balance
• mutants hold their heads to one side
• gait is disturbed with ataxia

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:61961


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory