Phenotypes Associated with This Genotype

Genotype
MGI:3801426

• Allelic Composition: Mcl1^tm1Ywh/Mcl1^tm1Ywh; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:137502 )

N • despite reduced neutrophil numbers and recruitment, the number of monocytes, recruitment of macrophages during peritonitis and macrophage survival and cytokine production after Toll-like receptor stimulation are normal

increased eosinophil cell number ( J:137502 )

• in the blood, spleen and bone marrow

decreased granulocyte number ( J:137502 )

• the number of Mac-1+Gr1+ granulocytes is decreased in the bone marrow as well as decreased 80% in peripheral blood and 86% in spleen compared to in wild-type mice

decreased neutrophil cell number ( J:137502 )

• the number of neutrophils is reduced by 80% compared to in wild-type mice due to increased apoptosis of neutrophils

• however, mice that do not exhibit proper cre-mediated deletion survive

abnormal neutrophil physiology ( J:137502 )

• apoptosis of neutrophils is enhanced

• however, mice that do not exhibit proper cre-mediated deletion survive

impaired neutrophil recruitment ( J:137502 )

• mice exhibit an 80% decrease in neutrophils recruited to peritoneal cells treated with thioglycollate to induce peritonitis compared to similarly treated wild-type mice

hematopoietic system

increased eosinophil cell number ( J:137502 )

• in the blood, spleen and bone marrow

decreased granulocyte number ( J:137502 )

• the number of Mac-1+Gr1+ granulocytes is decreased in the bone marrow as well as decreased 80% in peripheral blood and 86% in spleen compared to in wild-type mice

decreased neutrophil cell number ( J:137502 )

• the number of neutrophils is reduced by 80% compared to in wild-type mice due to increased apoptosis of neutrophils

• however, mice that do not exhibit proper cre-mediated deletion survive

abnormal neutrophil physiology ( J:137502 )

• apoptosis of neutrophils is enhanced

• however, mice that do not exhibit proper cre-mediated deletion survive

impaired neutrophil recruitment ( J:137502 )

• mice exhibit an 80% decrease in neutrophils recruited to peritoneal cells treated with thioglycollate to induce peritonitis compared to similarly treated wild-type mice