Phenotypes Associated with This Genotype

Genotype
MGI:3795938

• Allelic Composition: Hdac3^tm1Swh/Hdac3^tm1.1Swh; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

enlarged liver ( J:134288 )

• 2 weeks after the final pIpC injection liver size is increased about 2-fold

• gradual increase in hypertrophic hepatocytes with grainy cytoplasm following pIpC injections

increased liver weight ( J:134288 )

• 2 weeks after the final pIpC injection liver weight is increased about 2-fold

decreased liver glycogen level ( J:134288 )

• dramatic depletion of glycogen in hepatocytes after pIpC injections

abnormal hepatocyte morphology ( J:134288 )

• gradual increase in hypertrophic hepatocytes with grainy cytoplasm following pIpC injections

hepatic steatosis ( J:134288 )

• after pIpC injections

homeostasis/metabolism

decreased liver glycogen level ( J:134288 )

• dramatic depletion of glycogen in hepatocytes after pIpC injections

growth/size/body

enlarged liver ( J:134288 )

• 2 weeks after the final pIpC injection liver size is increased about 2-fold

• gradual increase in hypertrophic hepatocytes with grainy cytoplasm following pIpC injections

increased liver weight ( J:134288 )

• 2 weeks after the final pIpC injection liver weight is increased about 2-fold